Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis
Joint Authors
Sheng, Jun
Shi, Wei
Hayashi, Shuhei
Fang, Chongye
Tsutsui, Hiroko
Yu, Yang
Cai, Xianbin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15).
Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease.
There is currently no cure for this disease and few effective treatments are available.
Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases.
The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1.
PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1.
The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE.
Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE.
PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions.
These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.
American Psychological Association (APA)
Yu, Yang& Hayashi, Shuhei& Cai, Xianbin& Fang, Chongye& Shi, Wei& Tsutsui, Hiroko…[et al.]. 2014. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457780
Modern Language Association (MLA)
Yu, Yang…[et al.]. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-457780
American Medical Association (AMA)
Yu, Yang& Hayashi, Shuhei& Cai, Xianbin& Fang, Chongye& Shi, Wei& Tsutsui, Hiroko…[et al.]. Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-457780
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457780