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Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations
المؤلفون المشاركون
Mangino, Giorgio
De Falco, Elena
Coccia, Andrea
Pompilio, Giulio
Bastianelli, Daniela
Calogero, Antonella
Puca, Rosa
Bordin, Antonella
Siciliano, Camilla
Murdoch, Colin
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mesenchymal stem cells (MSCs) represent a promising cell population for cell therapy and regenerative medicine applications.
However, how variations in glucose are perceived by MSC pool is still unclear.
Since, glucose metabolism is cell type and tissue dependent, this must be considered when MSCs are derived from alternative sources such as the heart.
The zinc finger transcription factor Egr-1 is an important early response gene, likely to play a key role in the glucose-induced response.
Our aim was to investigate how short-term changes in in vitro glucose concentrations affect multipotent cardiac tissue-derived MSCs (cMSCs) in a mouse model of Egr-1 KO (Egr-1−/−).
Results showed that loss of Egr-1 does not significantly influence cMSC proliferation.
In contrast, responses to glucose variations were observed in wt but not in Egr-1−/− cMSCs by clonogenic assay.
Phenotype analysis by RT-PCR showed that cMSCs Egr-1−/− lost the ability to regulate the glucose transporters GLUT-1 and GLUT-4 and, as expected, the Egr-1 target genes VEGF, TGFβ-1, and p300.
Acetylated protein levels of H3 histone were impaired in Egr-1−/− compared to wt cMSCs.
We propose that Egr-1 acts as immediate glucose biological sensor in cMSCs after a short period of stimuli, likely inducing epigenetic modifications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bastianelli, Daniela& Siciliano, Camilla& Puca, Rosa& Coccia, Andrea& Murdoch, Colin& Bordin, Antonella…[et al.]. 2014. Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-457795
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bastianelli, Daniela…[et al.]. Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-457795
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bastianelli, Daniela& Siciliano, Camilla& Puca, Rosa& Coccia, Andrea& Murdoch, Colin& Bordin, Antonella…[et al.]. Influence of Egr-1 in Cardiac Tissue-Derived Mesenchymal Stem Cells in Response to Glucose Variations. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-457795
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457795
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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