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New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations
المؤلفون المشاركون
Darwish, Ibrahim A.
Abdine, Heba H.
Amer, Sawsan M.
al-Rayes, Lama I.
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-08-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
New simple and sensitive spectrophotometric and fluorimetric methods have been developed and validated for the determination of fluoxetine hydrochloride (FLX) in its pharmaceutical formulations.
The spectrophotometric method was based on the reaction of FLX with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium (pH 11) to form an orange-colored product that was measured at 490 nm.
The fluorimetric method was based on the reaction of FLX with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) in an alkaline medium (pH 8) to form a highly fluorescent product that was measured at 545 nm after excitation at 490 nm.
The variables affecting the reactions of FLX with both NQS and NBD-Cl were carefully studied and optimized.
The kinetics of the reactions were investigated, and the reaction mechanisms were presented.
Under the optimum reaction conditions, good linear relationships were found between the readings and the concentrations of FLX in the ranges of 0.3–6 and 0.035–0.5 μg mL−1 for the spectrophotometric and fluorimetric methods, respectively.
The limits of detection were 0.1 and 0.01 μg mL−1 for the spectrophotometric and fluorimetric methods, respectively.
Both methods were successfully applied to the determination of FLX in its pharmaceutical formulations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Darwish, Ibrahim A.& Amer, Sawsan M.& Abdine, Heba H.& al-Rayes, Lama I.. 2009. New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations. International Journal of Analytical Chemistry،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-457954
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Darwish, Ibrahim A.…[et al.]. New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations. International Journal of Analytical Chemistry No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-457954
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Darwish, Ibrahim A.& Amer, Sawsan M.& Abdine, Heba H.& al-Rayes, Lama I.. New Spectrophotometric and Fluorimetric Methods for Determination of Fluoxetine in Pharmaceutical Formulations. International Journal of Analytical Chemistry. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-457954
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457954
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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