Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation
المؤلفون المشاركون
Freeman, Michael D.
Kohles, Sean S.
المصدر
Journal of Environmental and Public Health
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-03
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Polychlorinated biphenyls (PCBs) are synthetic chlorinated hydrocarbons that have extensively polluted the environment and bioaccumulated in the food chain.
PCBs have been deemed to be probable carcinogens by the Environmental Protection Agency, and exposure to high levels of PCBs has been consistently linked to increased risk of non-Hodgkin lymphoma (NHL).
In the present article we present a forensic epidemiologic evaluation of the causal relationship between NHL and elevated PCB levels via application of the Bradford-Hill criteria.
Included in the evaluation is a meta-analysis of the results of previously published case-control studies in order to assess the strength of association between NHL and PCBs, resulting in an odds ratio in which the lowest percentile PCB concentration (quartile, quintile, or tertile) has been compared with the highest percentile concentration in the study groups.
The weight-adjusted odds ratio for all PCB congeners was 1.43 with a 95% confidence interval of 1.31 to 1.55, indicating a statistically significant causal association with NHL.
Because of the lack of an unexposed comparison group, a rationale for the use of a less than 2.0 relative risk causal contribution threshold is presented herein, including an ecologic analysis of NHL incidence and PCB accumulation (as measured by sales volume) over time.
The overall results presented here indicate a strong general causal association between NHL and PCB exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Freeman, Michael D.& Kohles, Sean S.. 2012. Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation. Journal of Environmental and Public Health،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-458136
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Freeman, Michael D.& Kohles, Sean S.. Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation. Journal of Environmental and Public Health No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-458136
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Freeman, Michael D.& Kohles, Sean S.. Plasma Levels of Polychlorinated Biphenyls, Non-Hodgkin Lymphoma, and Causation. Journal of Environmental and Public Health. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-458136
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458136
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر