Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems
المؤلفون المشاركون
Hinze, Thomas
Schumann, Mathias
Bodenstein, Christian
Schuster, Stefan
Heiland, Ines
المصدر
Computational Intelligence and Neuroscience
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences.
From a systems biological perspective, the question arises whether biological control systems for regulation of oscillatory signals and their technical counterparts utilise similar mechanisms.
If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for frequency control in circadian clocks along with gaining insight into mechanisms of clock synchronisation to external stimuli like the daily rhythm of sunlight and darkness.
Phase-locked loops could be an interesting candidate in this context.
Both, biology and engineering, can benefit from a unified view resulting from systems modularisation.
In a first experimental study, we analyse a model of coupled repressilators.
We demonstrate its ability to synchronise clock signals in a monofrequential manner.
Several oscillators initially deviate in phase difference and frequency with respect to explicit reaction and diffusion rates.
Accordingly, the duration of the synchronisation process depends on dedicated reaction and diffusion parameters whose settings still lack to be sufficiently captured analytically.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hinze, Thomas& Schumann, Mathias& Bodenstein, Christian& Heiland, Ines& Schuster, Stefan. 2011. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hinze, Thomas…[et al.]. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-458443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hinze, Thomas& Schumann, Mathias& Bodenstein, Christian& Heiland, Ines& Schuster, Stefan. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر