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Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems
Joint Authors
Hinze, Thomas
Schumann, Mathias
Bodenstein, Christian
Schuster, Stefan
Heiland, Ines
Source
Computational Intelligence and Neuroscience
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences.
From a systems biological perspective, the question arises whether biological control systems for regulation of oscillatory signals and their technical counterparts utilise similar mechanisms.
If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for frequency control in circadian clocks along with gaining insight into mechanisms of clock synchronisation to external stimuli like the daily rhythm of sunlight and darkness.
Phase-locked loops could be an interesting candidate in this context.
Both, biology and engineering, can benefit from a unified view resulting from systems modularisation.
In a first experimental study, we analyse a model of coupled repressilators.
We demonstrate its ability to synchronise clock signals in a monofrequential manner.
Several oscillators initially deviate in phase difference and frequency with respect to explicit reaction and diffusion rates.
Accordingly, the duration of the synchronisation process depends on dedicated reaction and diffusion parameters whose settings still lack to be sufficiently captured analytically.
American Psychological Association (APA)
Hinze, Thomas& Schumann, Mathias& Bodenstein, Christian& Heiland, Ines& Schuster, Stefan. 2011. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458443
Modern Language Association (MLA)
Hinze, Thomas…[et al.]. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-458443
American Medical Association (AMA)
Hinze, Thomas& Schumann, Mathias& Bodenstein, Christian& Heiland, Ines& Schuster, Stefan. Biochemical Frequency Control by Synchronisation of Coupled Repressilators : An In Silico Study of Modules for Circadian Clock Systems. Computational Intelligence and Neuroscience. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-458443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458443