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Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice
المؤلفون المشاركون
Chao, Yun-Peng
Hong, Hong-Jye
Kao, Shung-Te
Chiang, Chung-Jen
Lin, Chih-Che
Lin, Li-Jen
Wu, Chin-Jen
Wang, Shulhn-Der
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-04
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Urine therapy has been commonly practiced in ancient civilizations including those of India, China, and Greece.
The traditional Chinese medicine KWLL, the precipitation of human urine, has been used in China to alleviate the symptoms of asthma for thousands of years.
However, the mechanism of action by which KWLL exerts its immunotherapy is unclear.
This study attempted to elucidate the pharmacology of KWLL in mice that had been challenged recurrently by Dermatophagoides pteronyssinus (Der p).
BALB/c mice were orally administered KWLL (1 g/kg) before an intratracheal (i.t.) challenge of Der p.
Allergic airway inflammation and remodeling were provoked by repetitive Der p (50 μg/mice) challenges six times at 1 wk intervals.
Airway hypersensitivity, histological lung characteristics, and the expression profiles of cytokines and various genes were assessed.
KWLL reduced Der p-induced airway hyperresponsiveness and inhibited eosinophil infiltration by downregulating the protein expression of IL-5 in bronchoalveolar lavage fluid (BALF).
It also inhibited neutrophil recruitment by downregulating IL-17A in BALF.
KWLL effectively diminished inflammatory cells, goblet cell hyperplasia, and mRNA expression of IL-6 and IL-17A in the lung.
The reduction by KWLL of airway inflammatory and hyperresponsiveness in allergic asthmatic mice was mediated via immunomodulation of IL-5, IL-6, and IL-17A.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Chih-Che& Wang, Shulhn-Der& Lin, Li-Jen& Hong, Hong-Jye& Wu, Chin-Jen& Chiang, Chung-Jen…[et al.]. 2013. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458455
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Chih-Che…[et al.]. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458455
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Chih-Che& Wang, Shulhn-Der& Lin, Li-Jen& Hong, Hong-Jye& Wu, Chin-Jen& Chiang, Chung-Jen…[et al.]. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458455
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458455
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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