Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice
Joint Authors
Chao, Yun-Peng
Hong, Hong-Jye
Kao, Shung-Te
Chiang, Chung-Jen
Lin, Chih-Che
Lin, Li-Jen
Wu, Chin-Jen
Wang, Shulhn-Der
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Urine therapy has been commonly practiced in ancient civilizations including those of India, China, and Greece.
The traditional Chinese medicine KWLL, the precipitation of human urine, has been used in China to alleviate the symptoms of asthma for thousands of years.
However, the mechanism of action by which KWLL exerts its immunotherapy is unclear.
This study attempted to elucidate the pharmacology of KWLL in mice that had been challenged recurrently by Dermatophagoides pteronyssinus (Der p).
BALB/c mice were orally administered KWLL (1 g/kg) before an intratracheal (i.t.) challenge of Der p.
Allergic airway inflammation and remodeling were provoked by repetitive Der p (50 μg/mice) challenges six times at 1 wk intervals.
Airway hypersensitivity, histological lung characteristics, and the expression profiles of cytokines and various genes were assessed.
KWLL reduced Der p-induced airway hyperresponsiveness and inhibited eosinophil infiltration by downregulating the protein expression of IL-5 in bronchoalveolar lavage fluid (BALF).
It also inhibited neutrophil recruitment by downregulating IL-17A in BALF.
KWLL effectively diminished inflammatory cells, goblet cell hyperplasia, and mRNA expression of IL-6 and IL-17A in the lung.
The reduction by KWLL of airway inflammatory and hyperresponsiveness in allergic asthmatic mice was mediated via immunomodulation of IL-5, IL-6, and IL-17A.
American Psychological Association (APA)
Lin, Chih-Che& Wang, Shulhn-Der& Lin, Li-Jen& Hong, Hong-Jye& Wu, Chin-Jen& Chiang, Chung-Jen…[et al.]. 2013. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458455
Modern Language Association (MLA)
Lin, Chih-Che…[et al.]. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458455
American Medical Association (AMA)
Lin, Chih-Che& Wang, Shulhn-Der& Lin, Li-Jen& Hong, Hong-Jye& Wu, Chin-Jen& Chiang, Chung-Jen…[et al.]. Reduction of Airway Hyperresponsiveness by KWLL in Dermatophagoides-pteronyssinus-Challenged Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458455