In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests
المؤلفون المشاركون
Inoue, Kazumasa
Moriyama, Noriyuki
Yamaguchi, Masayuki
Mutou, Yasuko
Saji, Hideo
Fujii, Hirofumi
Ueda, Masashi
Kizaka-Kondoh, Shinae
Umeda, Izumi O.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Purpose.
We aimed to clearly visualize heterogeneous distribution of hypoxia-inducible factor 1α (HIF) activity in tumor tissues in vivo.
Methods.
We synthesized of 125I-IPOS, a 125I labeled chimeric protein probe, that would visualize HIF activity.
The biodistribution of 125I-IPOS in FM3A tumor-bearing mice was evaluated.
Then, the intratumoral localization of this probe was observed by autoradiography, and it was compared with histopathological findings.
The distribution of 125I-IPOS in tumors was imaged by a small animal SPECT/CT scanner.
The obtained in vivo SPECT-CT fusion images were compared with ex vivo images of excised tumors.
Fusion imaging with MRI was also examined.
Results.
125I-IPOS well accumulated in FM3A tumors.
The intratumoral distribution of 125I-IPOS by autoradiography was quite heterogeneous, and it partially overlapped with that of pimonidazole.
High-resolution SPECT-CT fusion images successfully demonstrated the heterogeneity of 125I-IPOS distribution inside tumors.
SPECT-MRI fusion images could give more detailed information about the intratumoral distribution of 125I-IPOS.
Conclusion.
High-resolution SPECT images successfully demonstrated heterogeneous intratumoral distribution of 125I-IPOS.
SPECT-CT fusion images, more favorably SPECT-MRI fusion images, would be useful to understand the features of heterogeneous intratumoral expression of HIF activity in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fujii, Hirofumi& Yamaguchi, Masayuki& Inoue, Kazumasa& Mutou, Yasuko& Ueda, Masashi& Saji, Hideo…[et al.]. 2012. In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-458482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fujii, Hirofumi…[et al.]. In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-458482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fujii, Hirofumi& Yamaguchi, Masayuki& Inoue, Kazumasa& Mutou, Yasuko& Ueda, Masashi& Saji, Hideo…[et al.]. In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-458482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر