HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells

المؤلفون المشاركون

Matayoshi, Akira
Kuang, Hai
Phonaphonh, Thongsavanh
Liang, Feixin
Sunagawa, Nao
Sunakawa, Hajime
Takemoto, Hiroyuki
Arasaki, Akira
Kina, Shinichiro
Arakaki, Keiichi

المصدر

Mediators of Inflammation

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-07-31

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

To date, the major role of HPV16E6 in cancer has been considered to be its ability to inhibit the p53 tumor-suppressor protein, thereby thwarting p53-mediated cytotoxic responses to cellular stress signals.

Here, we show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells (HPV16-positive squamous cell carcinoma of the cervix).

In addition, we examined the role of HPV16E6 in TGF-α-induced c-fos expression and found that the c-fos protein expression induced by TGF-α is HPV16E6 dependent.

Thus, our results provide the first evidence that HPV16E6 contributes to AP-1 complex formation after both ligand-dependent and independent EGFR activation, suggesting a new therapeutic approach to the treatment of HPV-associated tumors.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liang, Feixin& Kina, Shinichiro& Takemoto, Hiroyuki& Matayoshi, Akira& Phonaphonh, Thongsavanh& Sunagawa, Nao…[et al.]. 2011. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458520

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liang, Feixin…[et al.]. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-458520

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liang, Feixin& Kina, Shinichiro& Takemoto, Hiroyuki& Matayoshi, Akira& Phonaphonh, Thongsavanh& Sunagawa, Nao…[et al.]. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458520

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-458520