HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells
Joint Authors
Matayoshi, Akira
Kuang, Hai
Phonaphonh, Thongsavanh
Liang, Feixin
Sunagawa, Nao
Sunakawa, Hajime
Takemoto, Hiroyuki
Arasaki, Akira
Kina, Shinichiro
Arakaki, Keiichi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
To date, the major role of HPV16E6 in cancer has been considered to be its ability to inhibit the p53 tumor-suppressor protein, thereby thwarting p53-mediated cytotoxic responses to cellular stress signals.
Here, we show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells (HPV16-positive squamous cell carcinoma of the cervix).
In addition, we examined the role of HPV16E6 in TGF-α-induced c-fos expression and found that the c-fos protein expression induced by TGF-α is HPV16E6 dependent.
Thus, our results provide the first evidence that HPV16E6 contributes to AP-1 complex formation after both ligand-dependent and independent EGFR activation, suggesting a new therapeutic approach to the treatment of HPV-associated tumors.
American Psychological Association (APA)
Liang, Feixin& Kina, Shinichiro& Takemoto, Hiroyuki& Matayoshi, Akira& Phonaphonh, Thongsavanh& Sunagawa, Nao…[et al.]. 2011. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458520
Modern Language Association (MLA)
Liang, Feixin…[et al.]. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-458520
American Medical Association (AMA)
Liang, Feixin& Kina, Shinichiro& Takemoto, Hiroyuki& Matayoshi, Akira& Phonaphonh, Thongsavanh& Sunagawa, Nao…[et al.]. HPV16E6-Dependent c-Fos Expression Contributes to AP-1 Complex Formation in SiHa Cells. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-458520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458520