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Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?
المؤلفون المشاركون
Gónzalez-Mateo, Guadalupe
Loureiro, Jesús
Aguilera Peralta, Abelardo
Selgas, Rafael
López-Cabrera, Manuel
Jimenez-Heffernan, J. A.
المصدر
International Journal of Nephrology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions, such as peritoneal dialysis (PD), can lead to peritoneal fibrosis.
The maximum expression of sclerotic peritoneal syndromes (SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists.
The SPS includes a wide range of peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not.
EPS is a serious complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous tissue formation which cover and constrict the viscera.
Recent studies show that transdifferentiated mesothelial cells isolated from the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with PD function (lower ultrafiltration and high Cr-MTC).
In addition, in peritoneal biopsies from PD patients, the MMT correlates very well with anatomical changes (fibrosis and angiogenesis).
However, the pathway to reach EPS from SPS has not been fully and completely established.
Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loureiro, Jesús& Gónzalez-Mateo, Guadalupe& Jimenez-Heffernan, J. A.& Selgas, Rafael& López-Cabrera, Manuel& Aguilera Peralta, Abelardo. 2013. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loureiro, Jesús…[et al.]. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loureiro, Jesús& Gónzalez-Mateo, Guadalupe& Jimenez-Heffernan, J. A.& Selgas, Rafael& López-Cabrera, Manuel& Aguilera Peralta, Abelardo. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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