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Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?
Joint Authors
Gónzalez-Mateo, Guadalupe
Loureiro, Jesús
Aguilera Peralta, Abelardo
Selgas, Rafael
López-Cabrera, Manuel
Jimenez-Heffernan, J. A.
Source
International Journal of Nephrology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions, such as peritoneal dialysis (PD), can lead to peritoneal fibrosis.
The maximum expression of sclerotic peritoneal syndromes (SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists.
The SPS includes a wide range of peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not.
EPS is a serious complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous tissue formation which cover and constrict the viscera.
Recent studies show that transdifferentiated mesothelial cells isolated from the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with PD function (lower ultrafiltration and high Cr-MTC).
In addition, in peritoneal biopsies from PD patients, the MMT correlates very well with anatomical changes (fibrosis and angiogenesis).
However, the pathway to reach EPS from SPS has not been fully and completely established.
Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS.
American Psychological Association (APA)
Loureiro, Jesús& Gónzalez-Mateo, Guadalupe& Jimenez-Heffernan, J. A.& Selgas, Rafael& López-Cabrera, Manuel& Aguilera Peralta, Abelardo. 2013. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458527
Modern Language Association (MLA)
Loureiro, Jesús…[et al.]. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-458527
American Medical Association (AMA)
Loureiro, Jesús& Gónzalez-Mateo, Guadalupe& Jimenez-Heffernan, J. A.& Selgas, Rafael& López-Cabrera, Manuel& Aguilera Peralta, Abelardo. Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?. International Journal of Nephrology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-458527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458527