Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics
المؤلفون المشاركون
Zhang, Zhen
Gao, Haiqing
Yin, Mei
Lu, Weida
Li, Baoying
Cai, Qian
Yu, Fei
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Patients with diabetes often develop hypertension and atherosclerosis leading to cardiovascular disease.
However, some diabetic patients develop heart failure without hypertension and coronary artery disease, a process termed diabetic cardiomyopathy.
Phlorizin has been reported to be effective as an antioxidant in treating diabetes mellitus, but little is known about its cardioprotective effects on diabetic cardiomyopathy.
In this study, we investigated the role of phlorizin in preventing diabetic cardiomyopathy in db/db mice.
We found that phlorizin significantly decreased body weight gain and the levels of serum fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), and advanced glycation end products (AGEs).
Morphologic observations showed that normal myocardial structure was better preserved after phlorizin treatment.
Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomics, we identified differentially expressed proteins involved in cardiac lipid metabolism, mitochondrial function, and cardiomyopathy, suggesting that phlorizin may prevent the development of diabetic cardiomyopathy by regulating the expression of key proteins in these processes.
We used ingenuity pathway analysis (IPA) to generate an interaction network to map the pathways containing these proteins.
Our findings provide important information about the mechanism of diabetic cardiomyopathy and also suggest that phlorizin may be a novel therapeutic approach for the treatment of diabetic cardiomyopathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cai, Qian& Li, Baoying& Yu, Fei& Lu, Weida& Zhang, Zhen& Yin, Mei…[et al.]. 2013. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458579
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cai, Qian…[et al.]. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458579
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cai, Qian& Li, Baoying& Yu, Fei& Lu, Weida& Zhang, Zhen& Yin, Mei…[et al.]. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458579
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458579
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر