Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics
Joint Authors
Zhang, Zhen
Gao, Haiqing
Yin, Mei
Lu, Weida
Li, Baoying
Cai, Qian
Yu, Fei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Patients with diabetes often develop hypertension and atherosclerosis leading to cardiovascular disease.
However, some diabetic patients develop heart failure without hypertension and coronary artery disease, a process termed diabetic cardiomyopathy.
Phlorizin has been reported to be effective as an antioxidant in treating diabetes mellitus, but little is known about its cardioprotective effects on diabetic cardiomyopathy.
In this study, we investigated the role of phlorizin in preventing diabetic cardiomyopathy in db/db mice.
We found that phlorizin significantly decreased body weight gain and the levels of serum fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), and advanced glycation end products (AGEs).
Morphologic observations showed that normal myocardial structure was better preserved after phlorizin treatment.
Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomics, we identified differentially expressed proteins involved in cardiac lipid metabolism, mitochondrial function, and cardiomyopathy, suggesting that phlorizin may prevent the development of diabetic cardiomyopathy by regulating the expression of key proteins in these processes.
We used ingenuity pathway analysis (IPA) to generate an interaction network to map the pathways containing these proteins.
Our findings provide important information about the mechanism of diabetic cardiomyopathy and also suggest that phlorizin may be a novel therapeutic approach for the treatment of diabetic cardiomyopathy.
American Psychological Association (APA)
Cai, Qian& Li, Baoying& Yu, Fei& Lu, Weida& Zhang, Zhen& Yin, Mei…[et al.]. 2013. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458579
Modern Language Association (MLA)
Cai, Qian…[et al.]. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-458579
American Medical Association (AMA)
Cai, Qian& Li, Baoying& Yu, Fei& Lu, Weida& Zhang, Zhen& Yin, Mei…[et al.]. Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in dbdb Mice by Quantitative Proteomics. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-458579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458579