Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication
المؤلفون المشاركون
Varela, César
Esparza, Leticia
Bleda, Silvia
López de Maturana, Ignacio
Acin, Francisco
de Haro, Joaquín
المصدر
International Journal of Inflammation
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Our aim is to investigate a possible association of circulating anti-beta2-glycoprotein I antibodies (ABGPI) with the endothelial dysfunction, nitric oxide bioactivity dysregulation, and the inflammatory status that surrounds peripheral arterial disease.
We carried out an observational translational study, including 50 male patients with intermittent claudication and a healthy control group of 10 male subjects, age and sex matched with the cases.
Flow-mediated arterial dilatation (FMAD) was assessed as a surrogate of endothelial dysfunction, and C-reactive protein (hsCRP) was determined as a marker of inflammation.
Nitrite plasma levels were measured by colorimetric analysis.
Circulating ABGPI titer was detected with indirect immunofluorescence.
Titers <1 : 10 represented the reference range and the lower detection limit of the test.
Circulating ABGPI titer ≥1 : 10 was detected in 21 (42%) patients and in none of the control subjects (P<0.01).
Patients with ABGPI titer ≥1 : 10 had a lower FMAD (P=0.01).
The CRP levels were higher in patients with ABGPI titer ≥1 : 10 (P=0.04).
The nitrite plasma levels were higher in patients with ABGPI titer ≥1 : 10 (P<0.01).
These data suggest that these circulating ABGPI may collaborate in the development of atherosclerosis; however, further prospective studies are required to establish a causal relationship.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Varela, César& de Haro, Joaquín& Bleda, Silvia& Esparza, Leticia& López de Maturana, Ignacio& Acin, Francisco. 2013. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458891
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Varela, César…[et al.]. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-458891
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Varela, César& de Haro, Joaquín& Bleda, Silvia& Esparza, Leticia& López de Maturana, Ignacio& Acin, Francisco. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458891
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458891
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر