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Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication
Joint Authors
Varela, César
Esparza, Leticia
Bleda, Silvia
López de Maturana, Ignacio
Acin, Francisco
de Haro, Joaquín
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our aim is to investigate a possible association of circulating anti-beta2-glycoprotein I antibodies (ABGPI) with the endothelial dysfunction, nitric oxide bioactivity dysregulation, and the inflammatory status that surrounds peripheral arterial disease.
We carried out an observational translational study, including 50 male patients with intermittent claudication and a healthy control group of 10 male subjects, age and sex matched with the cases.
Flow-mediated arterial dilatation (FMAD) was assessed as a surrogate of endothelial dysfunction, and C-reactive protein (hsCRP) was determined as a marker of inflammation.
Nitrite plasma levels were measured by colorimetric analysis.
Circulating ABGPI titer was detected with indirect immunofluorescence.
Titers <1 : 10 represented the reference range and the lower detection limit of the test.
Circulating ABGPI titer ≥1 : 10 was detected in 21 (42%) patients and in none of the control subjects (P<0.01).
Patients with ABGPI titer ≥1 : 10 had a lower FMAD (P=0.01).
The CRP levels were higher in patients with ABGPI titer ≥1 : 10 (P=0.04).
The nitrite plasma levels were higher in patients with ABGPI titer ≥1 : 10 (P<0.01).
These data suggest that these circulating ABGPI may collaborate in the development of atherosclerosis; however, further prospective studies are required to establish a causal relationship.
American Psychological Association (APA)
Varela, César& de Haro, Joaquín& Bleda, Silvia& Esparza, Leticia& López de Maturana, Ignacio& Acin, Francisco. 2013. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458891
Modern Language Association (MLA)
Varela, César…[et al.]. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-458891
American Medical Association (AMA)
Varela, César& de Haro, Joaquín& Bleda, Silvia& Esparza, Leticia& López de Maturana, Ignacio& Acin, Francisco. Circulating Anti-Beta2-Glycoprotein I Antibodies Are Associated with Endothelial Dysfunction, Inflammation, and High Nitrite Plasma Levels in Patients with Intermittent Claudication. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-458891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-458891