RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes
المؤلفون المشاركون
Saucedo, Renata
Mendoza-Lorenzo, Patricia
Zarate, Arturo
Ostrosky-Wegman, Patricia
Hernandez, Marcelino
Basurto, Lourdes
Puello, Edgardo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
This study aimed to examine possible genetic effects of some retinol binding protein-4 (RBP4) single nucleotide polymorphisms (SNPs) on the risk of gestational diabetes mellitus (GDM).
In addition, the SNPs were examined for their possible association with insulin resistance at 6 weeks after delivery.
Methods.
This was a prospective study of 100 women with GDM and 100 participants with normal gestation who were evaluated at gestational week 30 and 6 weeks postpartum.
Three SNPs of RBP4 (rs3758539, rs116736522, and rs34571439) were genotyped using TaqMan assay.
The genotype distributions between GDM patients and normal controls were analyzed using logistic regression models.
In addition, differences in clinical characteristics among subjects grouped by genotype were assessed using the analysis of covariance test.
Results.
The frequencies of the rare alleles were not significantly different between GDM patients and controls.
However, we identified two variants rs3758539 and rs34571439 associated with insulin levels and insulin resistance in women with previous GDM.
Conclusion.
Noncoding SNPs of the RBP4 gene are not associated with GDM, but two SNPs showed associations with insulin resistance and insulin levels in women with prior GDM.
Additional studies with increased sample size will be necessary in other GDM cohorts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saucedo, Renata& Zarate, Arturo& Basurto, Lourdes& Hernandez, Marcelino& Puello, Edgardo& Mendoza-Lorenzo, Patricia…[et al.]. 2014. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458991
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saucedo, Renata…[et al.]. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-458991
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saucedo, Renata& Zarate, Arturo& Basurto, Lourdes& Hernandez, Marcelino& Puello, Edgardo& Mendoza-Lorenzo, Patricia…[et al.]. RBP4 Gene Variants Are Associated with Insulin Resistance in Women with Previous Gestational Diabetes. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-458991
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458991
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر