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Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA
المؤلفون المشاركون
Amor-Coarasa, Alejandro
McGoron, Anthony J.
Gulec, Seza
Milera, Andrew
Carvajal, Denny
المصدر
International Journal of Molecular Imaging
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles.
The radioisotope used in our research was 68Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging.
Methods.
Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with 68Ga.
Labeling was performed at different temperatures and times.
68Ga purification settings were also tested and optimized.
Labeling yield and purity of relyophilized MAA microparticles were compared with those that were not relyophilized.
Results.
MAA particles kept their original size distribution after relyophilization.
Labeling yield was 98% at 75°C when a 68Ga purification system was used, compared to 80% with unpurified 68Ga.
Radiochemical purity was over 97% up to 4 hours after the labeling.
The relyophilized MAA and labeling method eliminate the need for centrifugation purification of the final product and simplify the labeling process.
Animal experiments demonstrated the high in vivo stability of the obtained PET agent with more than 95% of the activity remaining in the lungs after 4 hours.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& McGoron, Anthony J.. 2014. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459010
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amor-Coarasa, Alejandro…[et al.]. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-459010
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& McGoron, Anthony J.. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459010
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459010
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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