Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA
Joint Authors
Amor-Coarasa, Alejandro
McGoron, Anthony J.
Gulec, Seza
Milera, Andrew
Carvajal, Denny
Source
International Journal of Molecular Imaging
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Rapid developments in the field of medical imaging have opened new avenues for the use of positron emitting labeled microparticles.
The radioisotope used in our research was 68Ga, which is easy to obtain from a generator and has good nuclear properties for PET imaging.
Methods.
Commercially available macroaggregated albumin (MAA) microparticles were suspended in sterile saline, centrifuged to remove the free albumin and stannous chloride, relyophilized, and stored for later labeling with 68Ga.
Labeling was performed at different temperatures and times.
68Ga purification settings were also tested and optimized.
Labeling yield and purity of relyophilized MAA microparticles were compared with those that were not relyophilized.
Results.
MAA particles kept their original size distribution after relyophilization.
Labeling yield was 98% at 75°C when a 68Ga purification system was used, compared to 80% with unpurified 68Ga.
Radiochemical purity was over 97% up to 4 hours after the labeling.
The relyophilized MAA and labeling method eliminate the need for centrifugation purification of the final product and simplify the labeling process.
Animal experiments demonstrated the high in vivo stability of the obtained PET agent with more than 95% of the activity remaining in the lungs after 4 hours.
American Psychological Association (APA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& McGoron, Anthony J.. 2014. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459010
Modern Language Association (MLA)
Amor-Coarasa, Alejandro…[et al.]. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-459010
American Medical Association (AMA)
Amor-Coarasa, Alejandro& Milera, Andrew& Carvajal, Denny& Gulec, Seza& McGoron, Anthony J.. Lyophilized Kit for the Preparation of the PET Perfusion Agent [68Ga]-MAA. International Journal of Molecular Imaging. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-459010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459010