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Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
المؤلفون المشاركون
Simpson, Kenneth J.
Hayes, Peter C.
Hidalgo, Ernest
Pryde, E. Anne
Craig, Darren G.
Forbes, Stuart J.
Wigmore, Stephen J.
Lee, Patricia
المصدر
Case Reports in Transplantation
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-29
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation.
Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE.
Aims.
To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS.
Methods.
Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC).
Results.
HMGB1 levels were markedly higher in the SFSS patient (92.1 ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7–14.8) ng/mL) and HC (1.42 (1.38–1.56) ng/mL).
In contrast, sRAGE levels were lower in the SFSS patient (1.88 ng/mL) compared with the ALF patients (3.53 (2.66–12.37) ng/mL) and were similar to HC levels (1.40 (1.23–1.89) ng/mL).
Conclusion.
These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS.
Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Craig, Darren G.& Lee, Patricia& Pryde, E. Anne& Hidalgo, Ernest& Hayes, Peter C.& Wigmore, Stephen J.…[et al.]. 2014. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-459288
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Craig, Darren G.…[et al.]. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-459288
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Craig, Darren G.& Lee, Patricia& Pryde, E. Anne& Hidalgo, Ernest& Hayes, Peter C.& Wigmore, Stephen J.…[et al.]. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-459288
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459288
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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