![](/images/graphics-bg.png)
Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome
Joint Authors
Simpson, Kenneth J.
Hayes, Peter C.
Hidalgo, Ernest
Pryde, E. Anne
Craig, Darren G.
Forbes, Stuart J.
Wigmore, Stephen J.
Lee, Patricia
Source
Case Reports in Transplantation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Small-for-size syndrome (SFSS) occurs in the presence of insufficient liver mass to maintain normal function after liver transplantation.
Murine mortality following 85% hepatectomy can be reduced by the use of soluble receptor for advanced glycation end products (sRAGE) to scavenge damage-associated molecular patterns and prevent their engagement with membrane-bound RAGE.
Aims.
To explore serum levels of sRAGE, high-mobility group box-1 (HMGB1) protein, and other soluble inflammatory mediators in a fatal case of SFSS.
Methods.
Serum levels of HMGB1, sRAGE, IL-18, and other inflammatory mediators were measured by ELISA in a case of SFSS, and the results were compared with 8 patients with paracetamol-induced acute liver failure (ALF) and 6 healthy controls (HC).
Results.
HMGB1 levels were markedly higher in the SFSS patient (92.1 ng/mL) compared with the ALF patients (median (IQR) 11.4 (3.7–14.8) ng/mL) and HC (1.42 (1.38–1.56) ng/mL).
In contrast, sRAGE levels were lower in the SFSS patient (1.88 ng/mL) compared with the ALF patients (3.53 (2.66–12.37) ng/mL) and were similar to HC levels (1.40 (1.23–1.89) ng/mL).
Conclusion.
These results suggest an imbalance between pro- and anti-inflammatory innate immune pathways in SFSS.
Modulation of the HMGB1-RAGE axis may represent a future therapeutic avenue in this condition.
American Psychological Association (APA)
Craig, Darren G.& Lee, Patricia& Pryde, E. Anne& Hidalgo, Ernest& Hayes, Peter C.& Wigmore, Stephen J.…[et al.]. 2014. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-459288
Modern Language Association (MLA)
Craig, Darren G.…[et al.]. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-459288
American Medical Association (AMA)
Craig, Darren G.& Lee, Patricia& Pryde, E. Anne& Hidalgo, Ernest& Hayes, Peter C.& Wigmore, Stephen J.…[et al.]. Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Case Reports in Transplantation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-459288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459288