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Post-Kala-Azar Dermal Leishmaniasis : A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIVAIDS Patients
المؤلفون المشاركون
Elfaki, Mona Elfaki Eltahir
Zijlstra, Edward
Elkadaru, Abdelgadir Mohamed Yousif
Musa, Brema Younis
Khidir, Selma Abdelmoneim
Khalil, Eltahir Awad Gasim
El Hassan, Ahmed Mohamed
Musa, Ahmed Mudawi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Visceral leishmaniasis (VL) is a parasitic disease characterized by immune suppression.
Successful treatment is usually followed by immune reconstitution and a dermatosis called post-Kala-azar dermal leishmaniasis (PKDL).
Recently, PKDL was described as one of the immune reconstitution syndromes (IRISs) in HIV/VL patients on HAART.
This study aimed to present PKDL as a typical example of paradoxical IRIS in non-HIV/AIDS individuals.
Published and new data on the pathogenesis and healing of PKDL was reviewed and presented.
The data suggested that PKDL is a typical example of paradoxical IRIS, being a new disease entity that follows VL successful treatment and immune recovery.
PKDL lesions are immune inflammatory in nature with granuloma, adequate response to immunochemotherapy, and an ensuing hypersensitivity reaction, the leishmanin skin test (LST).
The data also suggested that the cytokine patterns of PKDL pathogenesis and healing are probably as follows: an active disease state dominated by IL-10 followed by spontaneous/treatment-induced IL-12 priming, IL-2 stimulation, and INF-γ production.
INF-γ-activated macrophages eliminate the Leishmania parasites/antigen to be followed by LST conversion and healing.
In conclusion, PKDL is a typical example of paradoxical IRIS in non-HIV/AIDS individuals with anti-inflammatory cytokine patterns that are superseded by treatment-induced proinflammatory cytokines and lesions healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalil, Eltahir Awad Gasim& Khidir, Selma Abdelmoneim& Musa, Ahmed Mudawi& Musa, Brema Younis& Elfaki, Mona Elfaki Eltahir& Elkadaru, Abdelgadir Mohamed Yousif…[et al.]. 2013. Post-Kala-Azar Dermal Leishmaniasis : A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIVAIDS Patients. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459541
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalil, Eltahir Awad Gasim…[et al.]. Post-Kala-Azar Dermal Leishmaniasis : A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIVAIDS Patients. Journal of Tropical Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-459541
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalil, Eltahir Awad Gasim& Khidir, Selma Abdelmoneim& Musa, Ahmed Mudawi& Musa, Brema Younis& Elfaki, Mona Elfaki Eltahir& Elkadaru, Abdelgadir Mohamed Yousif…[et al.]. Post-Kala-Azar Dermal Leishmaniasis : A Paradigm of Paradoxical Immune Reconstitution Syndrome in Non-HIVAIDS Patients. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-459541
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459541
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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