Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses
المؤلفون المشاركون
Kawahara, Masahiro
Kato-Negishi, Midori
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-08
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Whilst being environmentally abundant, aluminum is not essential for life.
On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans.
The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease (AD) has been suggested.
In particular, the link between aluminum and Alzheimer's disease has been the subject of scientific debate for several decades.
However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established.
Mounting evidence has suggested that significance of oligomerization of β-amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis.
Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization.
Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures.
Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of β-amyloid oligomerization and the interactions with other metals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kawahara, Masahiro& Kato-Negishi, Midori. 2011. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-459642
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawahara, Masahiro& Kato-Negishi, Midori. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-459642
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kawahara, Masahiro& Kato-Negishi, Midori. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-459642
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459642
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر