Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses
Joint Authors
Kawahara, Masahiro
Kato-Negishi, Midori
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Whilst being environmentally abundant, aluminum is not essential for life.
On the contrary, aluminum is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans.
The relationship between aluminum exposure and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii Peninsula and Guam, and Alzheimer's disease (AD) has been suggested.
In particular, the link between aluminum and Alzheimer's disease has been the subject of scientific debate for several decades.
However, the complex characteristics of aluminum bioavailability make it difficult to evaluate its toxicity and therefore, the relationship remains to be established.
Mounting evidence has suggested that significance of oligomerization of β-amyloid protein and neurotoxicity in the molecular mechanism of AD pathogenesis.
Aluminum may play crucial roles as a cross-linker in β-amyloid oligomerization.
Here, we review the detailed characteristics of aluminum neurotoxicity based on our own studies and the recent literatures.
Our aim is to revisit the link between aluminum and AD and to integrate aluminum and amyloid cascade hypotheses in the context of β-amyloid oligomerization and the interactions with other metals.
American Psychological Association (APA)
Kawahara, Masahiro& Kato-Negishi, Midori. 2011. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-459642
Modern Language Association (MLA)
Kawahara, Masahiro& Kato-Negishi, Midori. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-459642
American Medical Association (AMA)
Kawahara, Masahiro& Kato-Negishi, Midori. Link between Aluminum and the Pathogenesis of Alzheimer's Disease : The Integration of the Aluminum and Amyloid Cascade Hypotheses. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-459642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-459642