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Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study
المؤلفون المشاركون
Kumar, Amit
Prasad, Kameshwar
Bal, Chandrashekar
Srivastava, Achal
Srivastava, M. V. P.
Gaikwad, Shailesh B.
Bhatia, Rohit
Sahu, Jitendra Kumar
Mishra, Nalini Kant
Goyal, Vinay
Mohanty, Sujata
Tripathi, Manjari
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke.
Aims.
To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke.
Patients and Method.
In randomized study, 10 patients with acute ischemic stroke were recruited in 1 : 1 ratio to receive 10 μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone.
Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale.
Results.
One patient in G-CSF therapy arm died due to raised intracranial pressure.
No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm.
No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group.
Conclusion.
Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy.
Further studies need to be done on a large sample to confirm the results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prasad, Kameshwar& Kumar, Amit& Sahu, Jitendra Kumar& Srivastava, M. V. P.& Mohanty, Sujata& Bhatia, Rohit…[et al.]. 2011. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prasad, Kameshwar…[et al.]. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-460188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prasad, Kameshwar& Kumar, Amit& Sahu, Jitendra Kumar& Srivastava, M. V. P.& Mohanty, Sujata& Bhatia, Rohit…[et al.]. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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