Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study
Joint Authors
Kumar, Amit
Prasad, Kameshwar
Bal, Chandrashekar
Srivastava, Achal
Srivastava, M. V. P.
Gaikwad, Shailesh B.
Bhatia, Rohit
Sahu, Jitendra Kumar
Mishra, Nalini Kant
Goyal, Vinay
Mohanty, Sujata
Tripathi, Manjari
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
There is emerging evidence to support the use of granulocyte colony-stimulating factor (G-CSF) therapy in patients with acute ischemic stroke.
Aims.
To explore feasibility, safety, and preliminary efficacy of G-CSF therapy in patients with acute ischemic stroke.
Patients and Method.
In randomized study, 10 patients with acute ischemic stroke were recruited in 1 : 1 ratio to receive 10 μg/kg G-CSF treatment subcutaneously daily for five days with conventional care or conventional treatment alone.
Efficacy outcome measures were assessed at baseline, one month, and after six months of treatment included Barthel Index (BI), National Institute of Health Stroke Scale, and modified Rankin Scale.
Results.
One patient in G-CSF therapy arm died due to raised intracranial pressure.
No severe adverse effects were seen in rest of patients receiving G-CSF therapy arm or control arm.
No statistically significant difference between intervention and control was observed in any of the scores though a trend of higher improvement of BI score is seen in the intervention group.
Conclusion.
Although this study did not have power to examine efficacy, it provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy.
Further studies need to be done on a large sample to confirm the results.
American Psychological Association (APA)
Prasad, Kameshwar& Kumar, Amit& Sahu, Jitendra Kumar& Srivastava, M. V. P.& Mohanty, Sujata& Bhatia, Rohit…[et al.]. 2011. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460188
Modern Language Association (MLA)
Prasad, Kameshwar…[et al.]. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-460188
American Medical Association (AMA)
Prasad, Kameshwar& Kumar, Amit& Sahu, Jitendra Kumar& Srivastava, M. V. P.& Mohanty, Sujata& Bhatia, Rohit…[et al.]. Mobilization of Stem Cells Using G-CSF for Acute Ischemic Stroke : A Randomized Controlled, Pilot Study. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-460188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460188