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Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial)
المؤلفون المشاركون
Ichihara, Atsuhiro
Bokuda, Kanako
Kurosawa, Hideaki
Itoh, Hiroshi
Kinouchi, Kenichiro
المصدر
International Journal of Hypertension
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background/Aims.
Arterial stiffness is an independent risk factor for cardiovascular morbidity and mortality.
This study was conducted to determine the effect of olmesartan (OLM) and azelnidipine (AZL) on arterial stiffness using the cardio-ankle vascular index (CAVI), which is a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients.
Methods.
Fifty-two consecutive hypertensive patients were randomly assigned either to a group treated with OLM monotherapy or to a group treated with OLM and AZL combination therapy.
Clinical and biological parameters were measured before and 12 months after the start of this study.
Results.
Both therapies significantly and similarly reduced BP, augmentation index, and plasma aldosterone levels.
The combination therapy significantly decreased CAVI and serum low-density lipoprotein (LDL-C) levels and these reductions were significantly greater than those produced with monotherapy.
No significant differences in metabolic parameters were observed between the two therapies.
Conclusion.
The combination therapy with OLM and AZL had beneficial effects on arterial stiffness assessed by CAVI, LDL-C, and metabolism, despite the similar BP reduction, compared with OLM monotherapy.
Since these markers are known to influence the future risk of cardiovascular events, combination therapy with OLM and AZL could be a useful choice for treating hypertensive patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kinouchi, Kenichiro& Ichihara, Atsuhiro& Bokuda, Kanako& Kurosawa, Hideaki& Itoh, Hiroshi. 2011. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-460316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kinouchi, Kenichiro…[et al.]. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-460316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kinouchi, Kenichiro& Ichihara, Atsuhiro& Bokuda, Kanako& Kurosawa, Hideaki& Itoh, Hiroshi. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-460316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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