Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial)
Joint Authors
Ichihara, Atsuhiro
Bokuda, Kanako
Kurosawa, Hideaki
Itoh, Hiroshi
Kinouchi, Kenichiro
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background/Aims.
Arterial stiffness is an independent risk factor for cardiovascular morbidity and mortality.
This study was conducted to determine the effect of olmesartan (OLM) and azelnidipine (AZL) on arterial stiffness using the cardio-ankle vascular index (CAVI), which is a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients.
Methods.
Fifty-two consecutive hypertensive patients were randomly assigned either to a group treated with OLM monotherapy or to a group treated with OLM and AZL combination therapy.
Clinical and biological parameters were measured before and 12 months after the start of this study.
Results.
Both therapies significantly and similarly reduced BP, augmentation index, and plasma aldosterone levels.
The combination therapy significantly decreased CAVI and serum low-density lipoprotein (LDL-C) levels and these reductions were significantly greater than those produced with monotherapy.
No significant differences in metabolic parameters were observed between the two therapies.
Conclusion.
The combination therapy with OLM and AZL had beneficial effects on arterial stiffness assessed by CAVI, LDL-C, and metabolism, despite the similar BP reduction, compared with OLM monotherapy.
Since these markers are known to influence the future risk of cardiovascular events, combination therapy with OLM and AZL could be a useful choice for treating hypertensive patients.
American Psychological Association (APA)
Kinouchi, Kenichiro& Ichihara, Atsuhiro& Bokuda, Kanako& Kurosawa, Hideaki& Itoh, Hiroshi. 2011. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-460316
Modern Language Association (MLA)
Kinouchi, Kenichiro…[et al.]. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-460316
American Medical Association (AMA)
Kinouchi, Kenichiro& Ichihara, Atsuhiro& Bokuda, Kanako& Kurosawa, Hideaki& Itoh, Hiroshi. Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial). International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-460316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460316