Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
المؤلفون المشاركون
Fortes, Maria Rita Parise
Graviss, Edward A.
Araujo, João Pessoa
Oliveira, Larissa Ragozo Cardoso
Pereira, Ana Carla
da Silva, Weber Laurentino
Calvi, Sueli Aparecida
Peresi, Eliana
Ayres, Jairo Aparecido
da Costa, Érika Alessandra Pellison Nunes
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels.
Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3).
Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2.
The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peresi, Eliana& Oliveira, Larissa Ragozo Cardoso& da Silva, Weber Laurentino& da Costa, Érika Alessandra Pellison Nunes& Araujo, João Pessoa& Ayres, Jairo Aparecido…[et al.]. 2013. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peresi, Eliana…[et al.]. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-460339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peresi, Eliana& Oliveira, Larissa Ragozo Cardoso& da Silva, Weber Laurentino& da Costa, Érika Alessandra Pellison Nunes& Araujo, João Pessoa& Ayres, Jairo Aparecido…[et al.]. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر