Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment
Joint Authors
Fortes, Maria Rita Parise
Graviss, Edward A.
Araujo, João Pessoa
Oliveira, Larissa Ragozo Cardoso
Pereira, Ana Carla
da Silva, Weber Laurentino
Calvi, Sueli Aparecida
Peresi, Eliana
Ayres, Jairo Aparecido
da Costa, Érika Alessandra Pellison Nunes
Source
Tuberculosis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels.
Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3).
Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN-γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF −308 A allele with higher TNF-α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 −819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF-β plasma levels in PTB patients at T2.
The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 −819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.
American Psychological Association (APA)
Peresi, Eliana& Oliveira, Larissa Ragozo Cardoso& da Silva, Weber Laurentino& da Costa, Érika Alessandra Pellison Nunes& Araujo, João Pessoa& Ayres, Jairo Aparecido…[et al.]. 2013. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460339
Modern Language Association (MLA)
Peresi, Eliana…[et al.]. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-460339
American Medical Association (AMA)
Peresi, Eliana& Oliveira, Larissa Ragozo Cardoso& da Silva, Weber Laurentino& da Costa, Érika Alessandra Pellison Nunes& Araujo, João Pessoa& Ayres, Jairo Aparecido…[et al.]. Cytokine Polymorphisms, Their Influence and Levels in Brazilian Patients with Pulmonary Tuberculosis during Antituberculosis Treatment. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-460339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460339