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iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels
المؤلفون المشاركون
Ding, Hui
Chen, Wei
Chou, Kuo-Chen
Lin, Hao
Liu, Li
Deng, En-Ze
Yuan, Lu-Feng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Conotoxins are small disulfide-rich neurotoxic peptides, which can bind to ion channels with very high specificity and modulate their activities.
Over the last few decades, conotoxins have been the drug candidates for treating chronic pain, epilepsy, spasticity, and cardiovascular diseases.
According to their functions and targets, conotoxins are generally categorized into three types: potassium-channel type, sodium-channel type, and calcium-channel types.
With the avalanche of peptide sequences generated in the postgenomic age, it is urgent and challenging to develop an automated method for rapidly and accurately identifying the types of conotoxins based on their sequence information alone.
To address this challenge, a new predictor, called iCTX-Type, was developed by incorporating the dipeptide occurrence frequencies of a conotoxin sequence into a 400-D (dimensional) general pseudoamino acid composition, followed by the feature optimization procedure to reduce the sample representation from 400-D to 50-D vector.
The overall success rate achieved by iCTX-Type via a rigorous cross-validation was over 91%, outperforming its counterpart (RBF network).
Besides, iCTX-Type is so far the only predictor in this area with its web-server available, and hence is particularly useful for most experimental scientists to get their desired results without the need to follow the complicated mathematics involved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ding, Hui& Deng, En-Ze& Yuan, Lu-Feng& Liu, Li& Lin, Hao& Chen, Wei…[et al.]. 2014. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460472
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ding, Hui…[et al.]. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-460472
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ding, Hui& Deng, En-Ze& Yuan, Lu-Feng& Liu, Li& Lin, Hao& Chen, Wei…[et al.]. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460472
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460472
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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