iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels
Joint Authors
Ding, Hui
Chen, Wei
Chou, Kuo-Chen
Lin, Hao
Liu, Li
Deng, En-Ze
Yuan, Lu-Feng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Conotoxins are small disulfide-rich neurotoxic peptides, which can bind to ion channels with very high specificity and modulate their activities.
Over the last few decades, conotoxins have been the drug candidates for treating chronic pain, epilepsy, spasticity, and cardiovascular diseases.
According to their functions and targets, conotoxins are generally categorized into three types: potassium-channel type, sodium-channel type, and calcium-channel types.
With the avalanche of peptide sequences generated in the postgenomic age, it is urgent and challenging to develop an automated method for rapidly and accurately identifying the types of conotoxins based on their sequence information alone.
To address this challenge, a new predictor, called iCTX-Type, was developed by incorporating the dipeptide occurrence frequencies of a conotoxin sequence into a 400-D (dimensional) general pseudoamino acid composition, followed by the feature optimization procedure to reduce the sample representation from 400-D to 50-D vector.
The overall success rate achieved by iCTX-Type via a rigorous cross-validation was over 91%, outperforming its counterpart (RBF network).
Besides, iCTX-Type is so far the only predictor in this area with its web-server available, and hence is particularly useful for most experimental scientists to get their desired results without the need to follow the complicated mathematics involved.
American Psychological Association (APA)
Ding, Hui& Deng, En-Ze& Yuan, Lu-Feng& Liu, Li& Lin, Hao& Chen, Wei…[et al.]. 2014. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460472
Modern Language Association (MLA)
Ding, Hui…[et al.]. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-460472
American Medical Association (AMA)
Ding, Hui& Deng, En-Ze& Yuan, Lu-Feng& Liu, Li& Lin, Hao& Chen, Wei…[et al.]. iCTX-Type : A Sequence-Based Predictor for Identifying the Types of Conotoxins in Targeting Ion Channels. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-460472
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460472