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The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes
المؤلفون المشاركون
Xie, Chao
Hou, Wen-fang
Hong, Tian-pei
Wang, Yan-rong
Xiao, Wen-hua
Gao, Hong-wei
Wang, Hai-ning
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Aim.
To investigate whether pioglitazone had detrimental effects on biochemical markers of bone turnover in patients with type 2 diabetes (T2DM).
Methods.
Seventy patients with T2DM were included in this study.
The patients remained on their previous antihyperglycemic therapies during the trial.
Pioglitazone was then added on their regimen for 3 months.
Results.
After 3 months of treatment with pioglitazone, the levels of fasting blood glucose and HbA1c were significantly decreased (7.9±1.5 mmol/L versus 9.1±1.6 mmol/L and 7.1±1.0% versus 8.2±1.4%, resp., P<0.01), compared with baseline in the overall patients.
Serum concentrations of P1NP and BAP were significantly decreased from baseline (45.0±20.0 μg/L versus 40.6±17.9 μg/L and 13.23±4.7 μg/L versus 12.3±5.0 μg/L, resp., P<0.01) in female group, but not in male group.
The serum levels of OC and CTX were unchanged in both female and male subgroups.
In addition, the levels of serum BAP and P1NP were significantly decreased after pioglitazone treatment in postmenopausal subgroup, comparing with baseline.
Conclusion.
Pioglitazone inhibits bone formation and does not seem to affect bone resorption.
Postmenopausal female patients rather than premenopausal or male patients are particularly vulnerable to this side effect of pioglitazone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiao, Wen-hua& Wang, Yan-rong& Hou, Wen-fang& Xie, Chao& Wang, Hai-ning& Hong, Tian-pei…[et al.]. 2013. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiao, Wen-hua…[et al.]. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-460792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiao, Wen-hua& Wang, Yan-rong& Hou, Wen-fang& Xie, Chao& Wang, Hai-ning& Hong, Tian-pei…[et al.]. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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