The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes
Joint Authors
Xie, Chao
Hou, Wen-fang
Hong, Tian-pei
Wang, Yan-rong
Xiao, Wen-hua
Gao, Hong-wei
Wang, Hai-ning
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To investigate whether pioglitazone had detrimental effects on biochemical markers of bone turnover in patients with type 2 diabetes (T2DM).
Methods.
Seventy patients with T2DM were included in this study.
The patients remained on their previous antihyperglycemic therapies during the trial.
Pioglitazone was then added on their regimen for 3 months.
Results.
After 3 months of treatment with pioglitazone, the levels of fasting blood glucose and HbA1c were significantly decreased (7.9±1.5 mmol/L versus 9.1±1.6 mmol/L and 7.1±1.0% versus 8.2±1.4%, resp., P<0.01), compared with baseline in the overall patients.
Serum concentrations of P1NP and BAP were significantly decreased from baseline (45.0±20.0 μg/L versus 40.6±17.9 μg/L and 13.23±4.7 μg/L versus 12.3±5.0 μg/L, resp., P<0.01) in female group, but not in male group.
The serum levels of OC and CTX were unchanged in both female and male subgroups.
In addition, the levels of serum BAP and P1NP were significantly decreased after pioglitazone treatment in postmenopausal subgroup, comparing with baseline.
Conclusion.
Pioglitazone inhibits bone formation and does not seem to affect bone resorption.
Postmenopausal female patients rather than premenopausal or male patients are particularly vulnerable to this side effect of pioglitazone.
American Psychological Association (APA)
Xiao, Wen-hua& Wang, Yan-rong& Hou, Wen-fang& Xie, Chao& Wang, Hai-ning& Hong, Tian-pei…[et al.]. 2013. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460792
Modern Language Association (MLA)
Xiao, Wen-hua…[et al.]. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-460792
American Medical Association (AMA)
Xiao, Wen-hua& Wang, Yan-rong& Hou, Wen-fang& Xie, Chao& Wang, Hai-ning& Hong, Tian-pei…[et al.]. The Effects of Pioglitazone on Biochemical Markers of Bone Turnover in the Patients with Type 2 Diabetes. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-460792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460792