Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer
المؤلفون المشاركون
Phukaoloun, Monlika
Santos, Cheryl
Ghosh, Sunita
Dechaphunkul, Arunee
Graham, Kathryn
Mackey, John R.
Kanjanapradit, Kanet
المصدر
International Journal of Breast Cancer
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed.
Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both pro- and antitumoral effects.
As role of TIMP-1 in breast cancer is controversial, we aimed to determine the prognostic significance of TIMP-1 in breast cancer.
Methods.
A single center-based case-control study was applied.
Primary breast cancers from women with early stage disease treated with standard adjuvant therapy were analyzed by gene expression microarrays and immunohistochemistry for TIMP-1.
Results.
At the optimized cut-point, patients with high TIMP-1 RNA levels had a significantly shorter time to relapse, with a hazard ratio (HR) of 1.64 (P=0.04), but without significant differences in overall survival (HR 1.29, P=0.37).
Although cytoplasmic overexpression of TIMP-1 protein was not correlated with early relapse (HR 1.0, P=0.92), there was a tendency for short overall survival in patients with high expression (HR 1.41, P=0.21).
Conclusions.
Our data indicate that elevated TIMP-1 RNA levels are independently prognostic for early recurrence, and there is a tendency for association of high cytoplasmic TIMP-1 protein levels with short survival in primary breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dechaphunkul, Arunee& Phukaoloun, Monlika& Kanjanapradit, Kanet& Graham, Kathryn& Ghosh, Sunita& Santos, Cheryl…[et al.]. 2012. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dechaphunkul, Arunee…[et al.]. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-460808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dechaphunkul, Arunee& Phukaoloun, Monlika& Kanjanapradit, Kanet& Graham, Kathryn& Ghosh, Sunita& Santos, Cheryl…[et al.]. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر