Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer
Joint Authors
Phukaoloun, Monlika
Santos, Cheryl
Ghosh, Sunita
Dechaphunkul, Arunee
Graham, Kathryn
Mackey, John R.
Kanjanapradit, Kanet
Source
International Journal of Breast Cancer
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Introduction.
Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed.
Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both pro- and antitumoral effects.
As role of TIMP-1 in breast cancer is controversial, we aimed to determine the prognostic significance of TIMP-1 in breast cancer.
Methods.
A single center-based case-control study was applied.
Primary breast cancers from women with early stage disease treated with standard adjuvant therapy were analyzed by gene expression microarrays and immunohistochemistry for TIMP-1.
Results.
At the optimized cut-point, patients with high TIMP-1 RNA levels had a significantly shorter time to relapse, with a hazard ratio (HR) of 1.64 (P=0.04), but without significant differences in overall survival (HR 1.29, P=0.37).
Although cytoplasmic overexpression of TIMP-1 protein was not correlated with early relapse (HR 1.0, P=0.92), there was a tendency for short overall survival in patients with high expression (HR 1.41, P=0.21).
Conclusions.
Our data indicate that elevated TIMP-1 RNA levels are independently prognostic for early recurrence, and there is a tendency for association of high cytoplasmic TIMP-1 protein levels with short survival in primary breast cancer.
American Psychological Association (APA)
Dechaphunkul, Arunee& Phukaoloun, Monlika& Kanjanapradit, Kanet& Graham, Kathryn& Ghosh, Sunita& Santos, Cheryl…[et al.]. 2012. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460808
Modern Language Association (MLA)
Dechaphunkul, Arunee…[et al.]. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-460808
American Medical Association (AMA)
Dechaphunkul, Arunee& Phukaoloun, Monlika& Kanjanapradit, Kanet& Graham, Kathryn& Ghosh, Sunita& Santos, Cheryl…[et al.]. Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460808