Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy
المؤلفون المشاركون
Shao, Minglong
Wang, Guanjun
Cai, Lu
Cheng, Jie
Li, Xiao-kun
Zhang, Chi
Ma, Jisheng
Jin, Shunzi
Zhang, Guirong
Tong, Qingyue
Xing, Xiao
Li, Cai
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Repetitive exposure of diabetic mice to low-dose radiation (LDR) at 25 mGy could significantly attenuate diabetes-induced renal inflammation, oxidative damage, remodeling, and dysfunction, for which, however, the underlying mechanism remained unknown.
The present study explored the effects of LDR on the expression and function of Akt and Nrf2 in the kidney of diabetic mice.
C57BL/6J mice were used to induce type 1 diabetes with multiple low-dose streptozotocin.
Diabetic and age-matched control mice were irradiated with whole body X-rays at either single 25 mGy and 75 mGy or accumulated 75 mGy (25 mGy daily for 3 days) and then sacrificed at 1–12 h for examining renal Akt phosphorylation and Nrf2 expression and function.
We found that 75 mGy of X-rays can stimulate Akt signaling pathway and upregulate Nrf2 expression and function in diabetic kidneys; single exposure of 25 mGy did not, but three exposures to 25 mGy of X-rays could offer a similar effect as single exposure to 75 mGy on the stimulation of Akt phosphorylation and the upregulation of Nrf2 expression and transcription function.
These results suggest that single 75 mGy or multiple 25 mGy of X-rays can stimulate Akt phosphorylation and upregulate Nrf2 expression and function, which may explain the prevention of LDR against the diabetic nephropathy mentioned above.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xing, Xiao& Zhang, Chi& Shao, Minglong& Tong, Qingyue& Zhang, Guirong& Li, Cai…[et al.]. 2012. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460835
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xing, Xiao…[et al.]. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-460835
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xing, Xiao& Zhang, Chi& Shao, Minglong& Tong, Qingyue& Zhang, Guirong& Li, Cai…[et al.]. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460835
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460835
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر