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Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy
Joint Authors
Shao, Minglong
Wang, Guanjun
Cai, Lu
Cheng, Jie
Li, Xiao-kun
Zhang, Chi
Ma, Jisheng
Jin, Shunzi
Zhang, Guirong
Tong, Qingyue
Xing, Xiao
Li, Cai
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Repetitive exposure of diabetic mice to low-dose radiation (LDR) at 25 mGy could significantly attenuate diabetes-induced renal inflammation, oxidative damage, remodeling, and dysfunction, for which, however, the underlying mechanism remained unknown.
The present study explored the effects of LDR on the expression and function of Akt and Nrf2 in the kidney of diabetic mice.
C57BL/6J mice were used to induce type 1 diabetes with multiple low-dose streptozotocin.
Diabetic and age-matched control mice were irradiated with whole body X-rays at either single 25 mGy and 75 mGy or accumulated 75 mGy (25 mGy daily for 3 days) and then sacrificed at 1–12 h for examining renal Akt phosphorylation and Nrf2 expression and function.
We found that 75 mGy of X-rays can stimulate Akt signaling pathway and upregulate Nrf2 expression and function in diabetic kidneys; single exposure of 25 mGy did not, but three exposures to 25 mGy of X-rays could offer a similar effect as single exposure to 75 mGy on the stimulation of Akt phosphorylation and the upregulation of Nrf2 expression and transcription function.
These results suggest that single 75 mGy or multiple 25 mGy of X-rays can stimulate Akt phosphorylation and upregulate Nrf2 expression and function, which may explain the prevention of LDR against the diabetic nephropathy mentioned above.
American Psychological Association (APA)
Xing, Xiao& Zhang, Chi& Shao, Minglong& Tong, Qingyue& Zhang, Guirong& Li, Cai…[et al.]. 2012. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460835
Modern Language Association (MLA)
Xing, Xiao…[et al.]. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-460835
American Medical Association (AMA)
Xing, Xiao& Zhang, Chi& Shao, Minglong& Tong, Qingyue& Zhang, Guirong& Li, Cai…[et al.]. Low-Dose Radiation Activates Akt and Nrf2 in the Kidney of Diabetic Mice : A Potential Mechanism to Prevent Diabetic Nephropathy. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-460835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460835