Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers
المؤلفون المشاركون
Marder, David
Thanassi, Wendy
Hernandez, Beatriz
Terpeluk, Paul
Newell, Jeffery
Yesavage, Jerome A.
Noda, Art
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
To find a statistically significant separation point for the QuantiFERON Gold In-Tube (QFT) interferon gamma release assay that could define an optimal “retesting zone” for use in serially tested low-risk populations who have test “reversions” from initially positive to subsequently negative results.
Method.
Using receiver operating characteristic analysis (ROC) to analyze retrospective data collected from 3 major hospitals, we searched for predictors of reversion until statistically significant separation points were revealed.
A confirmatory regression analysis was performed on an additional sample.
Results.
In 575 initially positive US healthcare workers (HCWs), 300 (52.2%) had reversions, while 275 (47.8%) had two sequential positive tests.
The most statistically significant (Kappa = 0.48, chi-square = 131.0, P<0.001) separation point identified by the ROC for predicting reversion was the tuberculosis antigen minus-nil (TBag-nil) value at 1.11 International Units per milliliter (IU/mL).
The second separation point was found at TBag-nil at 0.72 IU/mL (Kappa = 0.16, chi-square = 8.2, P<0.01).
The model was validated by the regression analysis of 287 HCWs.
Conclusion.
Reversion likelihood increases as the TBag-nil approaches the manufacturer's cut-point of 0.35 IU/mL.
The most statistically significant separation point between those who test repeatedly positive and those who revert is 1.11 IU/mL.
Clinicians should retest low-risk individuals with initial QFT results < 1.11 IU/mL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thanassi, Wendy& Noda, Art& Hernandez, Beatriz& Newell, Jeffery& Terpeluk, Paul& Marder, David…[et al.]. 2012. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thanassi, Wendy…[et al.]. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-460850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thanassi, Wendy& Noda, Art& Hernandez, Beatriz& Newell, Jeffery& Terpeluk, Paul& Marder, David…[et al.]. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر