Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers
Joint Authors
Marder, David
Thanassi, Wendy
Hernandez, Beatriz
Terpeluk, Paul
Newell, Jeffery
Yesavage, Jerome A.
Noda, Art
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To find a statistically significant separation point for the QuantiFERON Gold In-Tube (QFT) interferon gamma release assay that could define an optimal “retesting zone” for use in serially tested low-risk populations who have test “reversions” from initially positive to subsequently negative results.
Method.
Using receiver operating characteristic analysis (ROC) to analyze retrospective data collected from 3 major hospitals, we searched for predictors of reversion until statistically significant separation points were revealed.
A confirmatory regression analysis was performed on an additional sample.
Results.
In 575 initially positive US healthcare workers (HCWs), 300 (52.2%) had reversions, while 275 (47.8%) had two sequential positive tests.
The most statistically significant (Kappa = 0.48, chi-square = 131.0, P<0.001) separation point identified by the ROC for predicting reversion was the tuberculosis antigen minus-nil (TBag-nil) value at 1.11 International Units per milliliter (IU/mL).
The second separation point was found at TBag-nil at 0.72 IU/mL (Kappa = 0.16, chi-square = 8.2, P<0.01).
The model was validated by the regression analysis of 287 HCWs.
Conclusion.
Reversion likelihood increases as the TBag-nil approaches the manufacturer's cut-point of 0.35 IU/mL.
The most statistically significant separation point between those who test repeatedly positive and those who revert is 1.11 IU/mL.
Clinicians should retest low-risk individuals with initial QFT results < 1.11 IU/mL.
American Psychological Association (APA)
Thanassi, Wendy& Noda, Art& Hernandez, Beatriz& Newell, Jeffery& Terpeluk, Paul& Marder, David…[et al.]. 2012. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460850
Modern Language Association (MLA)
Thanassi, Wendy…[et al.]. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-460850
American Medical Association (AMA)
Thanassi, Wendy& Noda, Art& Hernandez, Beatriz& Newell, Jeffery& Terpeluk, Paul& Marder, David…[et al.]. Delineating a Retesting Zone Using Receiver Operating Characteristic Analysis on Serial QuantiFERON Tuberculosis Test Results in US Healthcare Workers. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-460850
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-460850