Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis
المؤلفون المشاركون
Xu, Yun-Fei
Peng, Bo
Liu, Min
Yao, Xu-Dong
Zheng, Jun-Hua
Dong, Wei-Da
Hu, Yang-Yang
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Both circulating and urinary miRNAs may represent a potential noninvasive molecular biomarker capable of predicting chronic kidney disease, and, in the present study, we will investigate the serum and urinary levels of miR-155 in patients with nephrolithiasis.
Methods.
Serum and urinary levels of miR-155 are quantified in 60 patients with nephrolithiasis; the result was compared to 50 healthy volunteers.
Estimated glomerular filtration (eGFR) was calculated and, by simple regression analysis, the correlations of miR-155/eGFR and miR-155/CRP (C-reactive protein) levels were analyzed as well.
Results.
The median levels of serum and urinary levels of miR-155 are significantly higher in nephrolithiasis patients than in controls.
eGFR inversely correlates with urinary level of miR-155; CRP positively correlates with urinary miR-155.
Urinary level of miR-155 inversely correlates with urinary expression of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α and positively correlates with urinary expression of regulated upon activation, normal T-cell expressed, and secreted (RANTES).
Conclusion.
Serum and urinary levels of miR-155 were significantly elevated in patients with nephrolithiasis, and the upregulation of miR-155 was correlated with decline of eGFR and elevation of CRP.
Our results suggested that miR-155 might play important roles in the pathophysiology of nephrolithiasis via regulating inflammatory cytokines expression.
Further study on the molecular pathogenic mechanism and larger scale of clinical trial are required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Yang-Yang& Dong, Wei-Da& Xu, Yun-Fei& Yao, Xu-Dong& Peng, Bo& Liu, Min…[et al.]. 2014. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461251
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Yang-Yang…[et al.]. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-461251
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Yang-Yang& Dong, Wei-Da& Xu, Yun-Fei& Yao, Xu-Dong& Peng, Bo& Liu, Min…[et al.]. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461251
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461251
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر