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Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis
Joint Authors
Xu, Yun-Fei
Peng, Bo
Liu, Min
Yao, Xu-Dong
Zheng, Jun-Hua
Dong, Wei-Da
Hu, Yang-Yang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Both circulating and urinary miRNAs may represent a potential noninvasive molecular biomarker capable of predicting chronic kidney disease, and, in the present study, we will investigate the serum and urinary levels of miR-155 in patients with nephrolithiasis.
Methods.
Serum and urinary levels of miR-155 are quantified in 60 patients with nephrolithiasis; the result was compared to 50 healthy volunteers.
Estimated glomerular filtration (eGFR) was calculated and, by simple regression analysis, the correlations of miR-155/eGFR and miR-155/CRP (C-reactive protein) levels were analyzed as well.
Results.
The median levels of serum and urinary levels of miR-155 are significantly higher in nephrolithiasis patients than in controls.
eGFR inversely correlates with urinary level of miR-155; CRP positively correlates with urinary miR-155.
Urinary level of miR-155 inversely correlates with urinary expression of interleukin- (IL-) 1β, IL-6, and tumor necrosis factor- (TNF-) α and positively correlates with urinary expression of regulated upon activation, normal T-cell expressed, and secreted (RANTES).
Conclusion.
Serum and urinary levels of miR-155 were significantly elevated in patients with nephrolithiasis, and the upregulation of miR-155 was correlated with decline of eGFR and elevation of CRP.
Our results suggested that miR-155 might play important roles in the pathophysiology of nephrolithiasis via regulating inflammatory cytokines expression.
Further study on the molecular pathogenic mechanism and larger scale of clinical trial are required.
American Psychological Association (APA)
Hu, Yang-Yang& Dong, Wei-Da& Xu, Yun-Fei& Yao, Xu-Dong& Peng, Bo& Liu, Min…[et al.]. 2014. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461251
Modern Language Association (MLA)
Hu, Yang-Yang…[et al.]. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-461251
American Medical Association (AMA)
Hu, Yang-Yang& Dong, Wei-Da& Xu, Yun-Fei& Yao, Xu-Dong& Peng, Bo& Liu, Min…[et al.]. Elevated Levels of miR-155 in Blood and Urine from Patients with Nephrolithiasis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461251