Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation

المؤلفون المشاركون

Hillyard, Dianne Z.
McQuarrie, Emily P.
Mark, Patrick B.
Patel, Rajan K.
Stevens, Kathryn K.
Sands, William
Jardine, Alan G.

المصدر

International Journal of Nephrology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-08-09

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD.

It may be a biomarker or a direct toxin.

We assessed the relationship between FGF-23 and LVH in CKD using CMRI.

In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs.

FGF-23 concentration correlates negatively with eGFR and positively with LVMI.

FGF-23 was an independent predictor of LVH in CKD.

E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho.

This effect was attenuated in cells exposed to both FGF-23 and Klotho.

FGF-23 is an independent predictor of LVH as measured by CMRI.

We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium.

We do not prove causality with elevated FGF-23 and LVH.

Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Stevens, Kathryn K.& McQuarrie, Emily P.& Sands, William& Hillyard, Dianne Z.& Patel, Rajan K.& Mark, Patrick B.…[et al.]. 2011. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461377

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Stevens, Kathryn K.…[et al.]. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-461377

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Stevens, Kathryn K.& McQuarrie, Emily P.& Sands, William& Hillyard, Dianne Z.& Patel, Rajan K.& Mark, Patrick B.…[et al.]. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461377

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-461377