Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation
Joint Authors
Hillyard, Dianne Z.
McQuarrie, Emily P.
Mark, Patrick B.
Patel, Rajan K.
Stevens, Kathryn K.
Sands, William
Jardine, Alan G.
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD.
It may be a biomarker or a direct toxin.
We assessed the relationship between FGF-23 and LVH in CKD using CMRI.
In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs.
FGF-23 concentration correlates negatively with eGFR and positively with LVMI.
FGF-23 was an independent predictor of LVH in CKD.
E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho.
This effect was attenuated in cells exposed to both FGF-23 and Klotho.
FGF-23 is an independent predictor of LVH as measured by CMRI.
We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium.
We do not prove causality with elevated FGF-23 and LVH.
Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.
American Psychological Association (APA)
Stevens, Kathryn K.& McQuarrie, Emily P.& Sands, William& Hillyard, Dianne Z.& Patel, Rajan K.& Mark, Patrick B.…[et al.]. 2011. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461377
Modern Language Association (MLA)
Stevens, Kathryn K.…[et al.]. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-461377
American Medical Association (AMA)
Stevens, Kathryn K.& McQuarrie, Emily P.& Sands, William& Hillyard, Dianne Z.& Patel, Rajan K.& Mark, Patrick B.…[et al.]. Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-461377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461377