Fibroblast Growth Factor 23 Predicts Left Ventricular Mass and Induces Cell Adhesion Molecule Formation

Abstract EN

Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD.

It may be a biomarker or a direct toxin.

We assessed the relationship between FGF-23 and LVH in CKD using CMRI.

In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs.

FGF-23 concentration correlates negatively with eGFR and positively with LVMI.

FGF-23 was an independent predictor of LVH in CKD.

E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho.

This effect was attenuated in cells exposed to both FGF-23 and Klotho.

FGF-23 is an independent predictor of LVH as measured by CMRI.

We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium.

We do not prove causality with elevated FGF-23 and LVH.

Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.