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Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis
المؤلفون المشاركون
Marthick, James R.
Dickinson, Joanne L.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The genetic architecture underpinning prostate cancer is complex, polygenic and despite recent significant advances many questions remain.
Advances in genetic technologies have greatly improved our ability to identify genetic variants associated with complex disease including prostate cancer.
Genome-wide association studies (GWASs) and microarray gene expression studies have identified genetic associations with prostate cancer susceptibility and tumour development.
The integrins feature prominently in both studies examining the underlying genetic susceptibility and mechanisms driving prostate tumour development.
Integrins are cell adhesion molecules involved in extracellular and intracellular signalling and are imperative for tumour development, migration, and angiogenesis.
Although several integrins have been implicated in tumour development, the roles of integrin α2 and integrin α6 are the focus of this paper as evidence is now emerging that these integrins are implicit in prostate cancer susceptibility, cancer stem cell biology, angiogenesis, cell migration, and metastases to bone and represent potential biomarkers and therapeutic targets.
There currently exists an urgent need to develop tools that differentiate indolent from aggressive prostate cancers and predict how patients will respond to treatment.
This paper outlines the evidence supporting the use of α2 and α6 integrins in clinical applications for tailored patient treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marthick, James R.& Dickinson, Joanne L.. 2012. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461539
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marthick, James R.& Dickinson, Joanne L.. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-461539
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marthick, James R.& Dickinson, Joanne L.. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461539
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461539
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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