Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis
Joint Authors
Marthick, James R.
Dickinson, Joanne L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The genetic architecture underpinning prostate cancer is complex, polygenic and despite recent significant advances many questions remain.
Advances in genetic technologies have greatly improved our ability to identify genetic variants associated with complex disease including prostate cancer.
Genome-wide association studies (GWASs) and microarray gene expression studies have identified genetic associations with prostate cancer susceptibility and tumour development.
The integrins feature prominently in both studies examining the underlying genetic susceptibility and mechanisms driving prostate tumour development.
Integrins are cell adhesion molecules involved in extracellular and intracellular signalling and are imperative for tumour development, migration, and angiogenesis.
Although several integrins have been implicated in tumour development, the roles of integrin α2 and integrin α6 are the focus of this paper as evidence is now emerging that these integrins are implicit in prostate cancer susceptibility, cancer stem cell biology, angiogenesis, cell migration, and metastases to bone and represent potential biomarkers and therapeutic targets.
There currently exists an urgent need to develop tools that differentiate indolent from aggressive prostate cancers and predict how patients will respond to treatment.
This paper outlines the evidence supporting the use of α2 and α6 integrins in clinical applications for tailored patient treatment.
American Psychological Association (APA)
Marthick, James R.& Dickinson, Joanne L.. 2012. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461539
Modern Language Association (MLA)
Marthick, James R.& Dickinson, Joanne L.. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-461539
American Medical Association (AMA)
Marthick, James R.& Dickinson, Joanne L.. Emerging Putative Biomarkers : The Role of Alpha 2 and 6 Integrins in Susceptibility, Treatment, and Prognosis. Prostate Cancer. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-461539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461539