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Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata
المؤلفون المشاركون
Jacob, Jubi
Nambisan, Bala
Lakshmanan, Rajesh
Sreekala, Sreerag Ravikumar
Saraswathy Amma, Dileep Kumar Bhaskaran Nair
Sasidharan, Nishanth Kumar
المصدر
International Journal of Antibiotics
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The aim of this study is to investigate the antimicrobial compounds present in the lichen Usnea albopunctata.
Ethyl acetate extract was purified by silica gel column chromatography to obtain a major compound and the chemical structure was characterized by 1H-NMR, 13C-NMR, DEPT, 1H-1H COSY, HMQC, HMBC, UV, and HR-MS spectroscopic methods as protolichesterinic acid.
The antimicrobial activity was estimated by determination of the minimal inhibitory concentration by the broth microdilution method and agar disc diffusion method against thirteen human pathogenic bacterial and four fungal strains.
Protolichesterinic acid recorded significant broad spectrum antimicrobial property.
The best antibacterial activity was recorded against K.
pneumonia (0.25 μg/mL) and V.
cholerae (0.5 μg/mL).
Significant antifungal activity was recorded against T.
rubrum (0.12 μg/mL), which is significantly better than the standard antifungal agent.
Protolichesterinic acid is reported for the first time from Usnea albopunctata.
Antifungal activity of protolichesterinic acid against medically important fungi is also reported for the first time.
Thus the results of the present study suggest that protolichesterinic acid has significant antimicrobial activities and has the strong potential to be developed as an antimicrobial drug after further clinical evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Lakshmanan, Rajesh& Jacob, Jubi& Saraswathy Amma, Dileep Kumar Bhaskaran Nair& Nambisan, Bala. 2014. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sasidharan, Nishanth Kumar…[et al.]. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-461665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Lakshmanan, Rajesh& Jacob, Jubi& Saraswathy Amma, Dileep Kumar Bhaskaran Nair& Nambisan, Bala. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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