![](/images/graphics-bg.png)
Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata
Joint Authors
Jacob, Jubi
Nambisan, Bala
Lakshmanan, Rajesh
Sreekala, Sreerag Ravikumar
Saraswathy Amma, Dileep Kumar Bhaskaran Nair
Sasidharan, Nishanth Kumar
Source
International Journal of Antibiotics
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study is to investigate the antimicrobial compounds present in the lichen Usnea albopunctata.
Ethyl acetate extract was purified by silica gel column chromatography to obtain a major compound and the chemical structure was characterized by 1H-NMR, 13C-NMR, DEPT, 1H-1H COSY, HMQC, HMBC, UV, and HR-MS spectroscopic methods as protolichesterinic acid.
The antimicrobial activity was estimated by determination of the minimal inhibitory concentration by the broth microdilution method and agar disc diffusion method against thirteen human pathogenic bacterial and four fungal strains.
Protolichesterinic acid recorded significant broad spectrum antimicrobial property.
The best antibacterial activity was recorded against K.
pneumonia (0.25 μg/mL) and V.
cholerae (0.5 μg/mL).
Significant antifungal activity was recorded against T.
rubrum (0.12 μg/mL), which is significantly better than the standard antifungal agent.
Protolichesterinic acid is reported for the first time from Usnea albopunctata.
Antifungal activity of protolichesterinic acid against medically important fungi is also reported for the first time.
Thus the results of the present study suggest that protolichesterinic acid has significant antimicrobial activities and has the strong potential to be developed as an antimicrobial drug after further clinical evaluation.
American Psychological Association (APA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Lakshmanan, Rajesh& Jacob, Jubi& Saraswathy Amma, Dileep Kumar Bhaskaran Nair& Nambisan, Bala. 2014. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461665
Modern Language Association (MLA)
Sasidharan, Nishanth Kumar…[et al.]. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-461665
American Medical Association (AMA)
Sasidharan, Nishanth Kumar& Sreekala, Sreerag Ravikumar& Lakshmanan, Rajesh& Jacob, Jubi& Saraswathy Amma, Dileep Kumar Bhaskaran Nair& Nambisan, Bala. Protolichesterinic Acid : A Prominent Broad Spectrum Antimicrobial Compound from the Lichen Usnea albopunctata. International Journal of Antibiotics. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-461665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-461665