The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease
المؤلفون المشاركون
Shirzad, Mahmood
Mirzaei, Khadijeh
Eshaghi, Seyede Mahdieh
Hossein-Nezhad, Arash
Curletto, Bryon
Maghbooli, Zhila
Chen, Tai C.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We determined the association of vitamin D deficiency and the FokI polymorphism of the vitamin D receptor (VDR) gene in 760 patients who underwent angiography due to suspected coronary artery disease (CAD).
Angiography and the Rentrop scoring system were used to classify the severity of CAD in each patient and to grade the extent of collateral development, respectively.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the FokI VDR gene polymorphism.
The prevalence of severe vitamin D deficiency (serum 25(OH)D < 10 ng/mL) was significantly higher in patients with at least one stenotic coronary artery compared to those without any stenotic coronary arteries.
Severe vitamin D deficiency was not independently associated with collateralization, but it was significantly associated with the VDR genotypes.
In turn, VDR genotype was independently associated with the degree of collateralization; the Rentrop scores were the highest in FF, intermediate in Ff, and the lowest in the ff genotype.
The results show that FokI polymorphism is independently associated with collateralization.
Additionally, vitamin D deficiency is more prevalent in patients with CAD that may result from FokI polymorphism.
Therefore, maintaining a normal vitamin D status should be a high priority for patients with CAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hossein-Nezhad, Arash& Eshaghi, Seyede Mahdieh& Maghbooli, Zhila& Mirzaei, Khadijeh& Shirzad, Mahmood& Curletto, Bryon…[et al.]. 2014. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hossein-Nezhad, Arash…[et al.]. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-461850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hossein-Nezhad, Arash& Eshaghi, Seyede Mahdieh& Maghbooli, Zhila& Mirzaei, Khadijeh& Shirzad, Mahmood& Curletto, Bryon…[et al.]. The Role of Vitamin D Deficiency and Vitamin D Receptor Genotypes on the Degree of Collateralization in Patients with Suspected Coronary Artery Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-461850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر